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HAWI, Z., Kent, L., Hill, M., Anney,
R. J. L., Brookes, K-J., Barry, B., Franke, B., Banaschewski, T., Buitelaar,
J., Ebstein, R. P., Miranda, A., Oades, R. D., Roeyers, H., Rothenberger,
A., Sergeant, J. A., Sonuga-Barke, E. J. S., Steinhausen, H-C., Faraone,
S. V., Asherson, P., & Gill, M.
(2010) Background: We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. -- This was particularly clear in the case of the DAT1 3-UTR VNTR. Aims - Methods: Here we analyzed 3 new samples comprising of 1,248 ADHD nuclear families to examine the allelic over-transmission of DAT1 in ADHD. Results: 2 - In addition, a similar pattern of over-transmission of paternal risk haplotypes (constructed from the above alleles) was also observed. 3 - Some support is also derived from the 2 smaller samples although neither is independently significant. Discussion: Although the mechanism driving the paternal over-transmission of the DAT risk alleles is not known, these findings provide further support for this phenomenon. Support NIH and the Health Research Board, Dublin |