Oades, R. D., (1991) Bases for irrelevant information processing in schizophrenia: room for manoeuvre

The Behavioral and Brain Sciences, 14, 38-39 -- Commentary* on "The Neuropsychology of Schizophrenia", View Commentary

by J. A. Gray, J. Feldon, J. N. P. Rawlins, D. R. Hemsley & A. D. Smith et al., The Behavioral and Brain Sciences, 14, 1-84. View Abstract


The trend is to move away from the strong version of the dopamine (DA) hypothesis of schizophrenia.

What better way than with Gray et al.'s suggestion that the subicular-accumbens pathway is where the impairment can be observed in positive schizophrenia (PS)?

They incorporate current evidence of temporal lobe dysunction (the frontal lobe is largely put to one side), yet still allow for the partial therapeutic effect of D2 antagonism in those with PS. Is this reasonable?

A weakness of Hemsley's, Frith's and Gray's formulation of the psychological processes underlying PS is the over-use of dichotomies (Occam's Razor) to solve a heterogeneous problem ......