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ASHERSON, P.,
Brookes, K-J., Franke, B., Chen, W., Gill, M., Ebstein,
R., Buitelaar, J., Banaschewski, T., Sonuga-Barke, E. J. S., Eisenberg,
J., Manor, I., Miranda, A., Oades, R.D., Roeyers,
H., Rothenberger, A., Sergeant, J. A., Steinhausen, H-C., & Faraone,
S.V. (2007) Introduction: One
of the most prominent findings in genetics research on ADHD
is the association with the 10-repeat-allele of a variable
number tandem repeat (VNTR) in the 3'-untranslated region of the DA
transporter gene. -- Despite a large number of positive reports
the net-effect across studies is small with evidence for heterogeneity.
-- One source of heterogeneity could arise if the 10-repeat allele tags
a nearby functional variant (in partial linkage disequilibrium (LD)
with the 10-repeat allele, with different levels of LD occurring in
different populations) or interacts with another locus (additional DNA
variants in DAT1 gene). Brookes et al., 2006
Arch. Gen. Psychiat., 63, 74-81 reported the association
of ADHD with a sub-group of chromosomes, containing the 10-repeat-allele
& the 3-repeat-allele of another VNTR in intron 8 |