CHEN, W., Zhou,
K., Sham, P., Franke, B., Kuntsi, J., Campbell, D., Fleischman, K.,
Knight, J., Andreou, P., Arnold, R., Altink, M., Boer, F., Boholst,
M.J., Buschgens, C., Butler, L., Christiansen, H.,
Fliers, E., Howe-Forbes, R., Gabriëls,
I., Heise, A., Korn-Lubetzki, I., Marco, R., Medad, S., Minderaa, R.,
Müller, U.C., Mulligan, A., Psychogiou, L., Rommelse, N., Sethna,
V., Uebel, H., McGuffin, P., Plomin, R., Banaschewski, T., Buitelaar,
J., Ebstein, R., Eisenberg, J., Gill, M., Manor, I., Miranda, A., Mulas,
F., Oades, R. D., Roeyers,
H., Rothenberger, A., Sergeant, J. A.,, Sonuga-Barke, E. J. S.,, Steinhausen,
H. C., Taylor, E. A., Thompson, M., Faraone, S. V. & Asherson, P. Introduction: ADHD is a discrete clinical syndrome characterized by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments. Molecular genetic studies have been successful in identifying genetic variants associated with ADHD, particularly with DSM-IV inattentive & combined subtypes. -- Quantitative trait locus (QTL) approaches to linkage & association mapping have yet to be widely used in ADHD research, although twin studies investigating individual differences suggest that genetic liability for ADHD is continuously distributed throughout the population, underscoring the applicability of quantitative dimensional approaches. Methods: To investigate the appropriateness of QTL approaches, we tested the familial association between 894 cases with a research diagnosis of DSM-IV ADHD combined type (ct) & continuous trait measures among 1,135 of their siblings unselected for phenotype. Results: Conclusions: |