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Oades, R. D., Röpcke, B., Henning,
U., Klimke, A., & Rao M. L., (2002).
Neuropsychologic function, serum
monoamine activity, and dimensions of schizophrenia.
Schizophrenia Research, 53 (supplement), p. 148.
Introduction: Different aspects of information
processing (attention and memory) are modulated by high and low levels
or ratios of the monoamines dopamine (DA), noradrenaline (NA) and serotonin
(5-HT). Indicators of monoamine activity in turn characterise different
subgroups of schizophrenia (Oades
et al., 2002)..
Methods: We studied
a) the extent to which serum indicators of monoamine activity predicted
performance on ten neuropsychological measures reflecting lateralised
frontal, parietal and temporal lobe involvement (e.g.,
verbal fluency, trails, picture-completion, block-design, Stroop, Mooney-faces
and visual/verbal memory).
b) Serum levels of the 3 monoamines and their main metabolites taken
from 63 healthy controls and 108 patients with schizophrenia were analysed
with HPLC (i.e., Dopamine (DA), Noradrenaline
(NA), Serotonin (5-HT), Homovanillic acid (HVA), 3-methoxy-4-hydroxy-phenyl
glycol (MHPG), & 5-hydroxyindoleacetic acid (5-HIAA).
c) Subgroups were based on 4 PCA-derived dimensions of PANSS-SAPS symptom
ratings (paranoid, nonparanoid, thought disorder
and ideas-of-reference).
Results:
First:
a) For non-paranoid and thought-disordered patients verbal fluency
and Stroop-interference (left fronto-cingulate function) were
negatively associated with NA turnover:
b) but delayed verbal recall (left
temporal lobe function) showed a positive association.
Second:
a) Those with many ideas-of-reference showed a relationship between
trails (trails B-A) and high DA turnover.
b) Low DA turnover in non-paranoid patients and those
with little thought disorder related to poor immediate recall.
Third:
a) Visual-reproduction and Mooney-faces
performance was predicted by increased HVA/5-HIAA ratios,
b) but decreased HVA/MHPG predicted non-verbal recall.
Conclusions: In general, right hemisphere
functions appeared sensitive to the ratio
of the activity of DA to the other amines. Depending on the
symptom clusters expressed, --
-- low mesocortical DA activity may impair set-shifting and memory,
-- while NA activity was associated with enhanced frontal
but impaired temporal lobe function.
Support: DFG (OA 1/4-1&2)
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