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Oknina,L.,
Juran, S., Oades, R. D., Weisbrod,M. (a), Chan, E., Chen, E. Y. H. (b), Röpcke, B., (2004).
Frontal and temporal lobe sources for mismatch negativity
(MMN) in schizophrenia: an ERP and MR-anatomical imaging study.
Schizophrenia Research, 67 (supplement), p. 22.
Biopsychology Group, University Clinic for Child and Adolescent Psychiatry,
Essen, Germany: Oades@uni-essen.de. (a) University Psychiatry Clinic,
Heidelberg, Germany, (b) Queen Mary Hospital, University of Hong Kong,
PRC
.Introduction: MMN is an electrophysiological
measure of automatic auditory change detection. A smaller MMN in patients
with schizophrenia (Ref. 1, 2) may reflect
altered frontal activity (Ref. 3).
Methods: We studied
Following our report on the coordinates for frontal and temporal lobe
dipole-loci contributing to normal MMN (Ref. 4)
we replicated this result using brain electrical source analysis (BESA)
and MR-images of the brain in 14 healthy subjects (34.8y) and compared
it with 17 patients (32 y) 15 years after the onset of schizophrenia.
.
Results:
First:
a) For MMN associated with a frequency deviant tone asymmetric loci
in the superior-temporal and left anterior-cingulate gyri were replicated,
while that in the right inferior-frontal gyrus moved to the mid-frontal
border (residual variance [RV] <1%). turnover:
Second:
Patients showed a modest MMN reduction, a weaker left temporal lobe
source but essentially similar loci (RV~1%).
Third:
a) Discrete changes in the locus of left
temporal and cingulate sources were illustrated by plotting volumes
around the group solution for individual’s data to 2% RV, with
the radius illustrating the standard deviation of the distance to the
better solutions for other subjects’ loci (also using a 2% RV
criterion).
b) The left temporal lobe source was marginally more medial in patients
(5 mm, p<0.01), while the left cingulate was more rostral (10 mm,
p<0.0001).
Conclusions: The data show a degree of compensation of function
despite altered source locations in the left hemisphere.
1. Oades et al. 1995 EEG
Clin Neurophysiol 44, 428-438. (Oades
et al., 1995).
2. Umbricht et al 2002 Biol Psychiat 53, 1120-1131
3. Baldeweg et al 2002 Int J Psychophysiol 43, 111-122
4. Jemel et al 2002 Brain Topog 15, 13-27.
(Jemel
et al., 2002).
Dr. Oknina was supported by the Alfried Krupp
von Bohlen und Halbach Stiftung
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