Zhou, K., Dempfle, A., Arcos-Burgos, M., Bakker, S. C., Banaschewski, T., Biederman, J., Buitelaar, J. K., Castellanos, F. X., Dempfle, A., Doyle, A. E., Ebstein, R. P., Ekholm, J., Forabosco, P., Franke, B., Freitag, C., Friedel, S., Gill, M., Hebebrand, J., Hinney, A., Jacob, C., Lesch, K-P., Loo, S. K., Lopera, F., McCracken, J. T., McGough, J. J., Meyer, J., Mick, E., Miranda, A., Muenkel, M., Mulas, F., Nelson, S. F., Nguyen, T. T., Oades, R. D., Ogdie, M. N., Palacio, J. D., Pineda, D., Reif, A., Renner, T. J., Roeyers, H., Romanos, M., Rothenberger, A., Schäfer, H. Sergeant, J. A., Sinke, R. J., Smalley, S. L. Sonuga-Barke, E. J. S., Steinhausen, H-C. van der Meulen,E.., Walitza, A., Warnke, A, Lewis, C. M.; Faraone, S. V. & Asherson, P.

Meta-analysis of Genome-Wide Linkage Scans of Attention Deficit Hyperactivity Disorder. American Journal of Medical Genetics Part B, 147B, 1392-1398. DOI 10.1002/ajmg.b.30878. [Request a copy] [View whole article]

Introduction: A genetic contribution to the development of ADHD is well established. --- 7 independent genome-wide linkage scans-have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replication of linkage signals between the various independent data-sets.

Methods: Here we gathered the results from all 7 of the ADHD linkage-scans & performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies.

Results:
1 - Genome-wide significant linkage (PSR =0.00034, POR=0.04) was identified on chromosome 16 between 64Mb & 83Mb.

2 - CDH13, a gene found to be associated with ADHD symptoms counts in a quantitative trait analysis from a recent whole genome association scan, is located within this region & is a potential positional candidate giving rise to this linkage signal.

3 - In addition there are 9 other genomic regions from the GSMA showing nominal or suggestive evidence of linkage.

4 - There were bins on chromosomes 5, 6, 7, 8, 9, 15, 16, 17 showed nominal linkage signals (PSR < 0.05) from the un-weighted analysis.

Discussion: All these linkage results may be informative & focus the-search for-novel ADHD susceptibility genes.