Project
III
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Mismatch
negativity (MMN) |
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The Negative difference (Nd),
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We propose, a) a longitudinal examination of the MMN and Nd course at up to four time-points after the initial admission of patients with a first episode of schizophrenia, b) to compare patients with an early illness-onset (adolescents), often associated with a poor prognosis, with those showing a later onset (adults), c) to examine prospectively associations of the development of MMN and Nd with ratings of symptom clusters (subgroups), types of treatment and neuropsychological indicators of frontal and temporal lobe function implicated in the generation of these potentials, d) to examine retrospectively this development in terms of the type of premorbid and prodromal development, and d) to compare these data with calculation of the current dipole sources of the potentials and their accurate location within the brain. |
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The proposed study has three elements. 1. Tracking the subjects entering the care of child and adolescent psychiatry (prospective element), 2. A co-operative study to contrast the outcome of first-episode adolescent vs. first-episode adult schizophrenia (prospective and retrospective elements) and 3. The progress of patients originally admitted as adolescents, now 16-18 years later (pseudo-long-term study). |
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In summary
the aim is to relate psychophysiological measures of automatic and controlled
attentional processing to state and trait features of young first-episode
patients with schizophrenia, to relate these measures to their underlying
functional neurobiological bases, and to track their development within
a good and a poor course of the illness. |
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