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Thienel, R., Bender,
S., Oades, R. D., Dittmann-.Balcar, A., Rao, M. L., & Schall, U.
A. (2001). Auditory gating,
Neuropsychology and D2-occupamcy in a one-year follow-up treatment study
on schizophrenia.. Schizophrenia Research, 49, (supplement),
210.
Introduction:
Auditory gating was investigated in 46 first to third episode patients
diagnosed with schizophrenia (DSM-IV) -- they were followed up for one
year.
Methods:
Gating measures were the fronto-central difference waveforms (non-target-
minus target-elicited P300 evoked potentials) preceded by a 100 ms prepulse
in a Go/non-go auditory discrimination. [ This component is called the
prepulse - induced non- target positivity, PINTP, see Bender
et al., 1999]
Results:
1) At therapy onset, patients showed a
significantly smaller PINTP vs. 27 healthy controls.
2) Over one year patients' PINTP increased
significantly, in association with imporoved clinical ratings (PANSS:
difficulty in abstract thinking, conceptual disorganization, lack of
spontaneity and flow of conversation).
3) Over the same period the increase /
trend to normalization of PINTP also correlated with improved Tower-of-London
performance, and
4) with the course of neuroleptic dopamine
- D2 binding assessed by haloperidol displacement in an in vitro
striatal binding assay (Oades et al.,
2000a; and Oades
et al. 2000b).
Conclusions:
These findings indicate that neuroleptic dopamine-D2 receptor blockade
is associated with improved fronto-temporal information processing in
the brain during the course of treatment.. (Support: DFG Scha628/4-1)
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