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SCHALL, U., SCHÖN, A., ZERBIN, D., BENDER, S., EGGERS, C., & OADES, R. D. (1997). A left temporal lobe impairment of auditory information processing in schizophrenia: an event-related potential study. Neuroscience Letters, 229, 25-28. (request a copy) In accord with our understanding of journal policy,
we present the
pre-publication text (view). Introduction: A measure of auditory prepulse inhibition (PPI) or sensory gating is the reduction of the scalp-recorded P1 event-related potential (ERP) after a sound that is preceded by 100-300 ms by a click as prepulse. This measure of sensory gating was adapted to study the effect of a prepulse on processing tones that were part of a "Go/no-go" discrimination. Methods: ERPs were recorded at right and left frontal and temporal sites on the scalp of groups of patients with schizophrenia (SCH, 8), obsessive compulsive disorder (OCD, 10) and healthy controls (CON, 19). Results:
Conclusions: These results show a reduction of a PPI-like effect on early processing (e.g. P50/P1) that is more marked in the left hemisphere of SCH patients, and may affect channel selection for processing information about task-relevant sounds (e.g. N100) After our initial report on the Go/no-go
gating paradigm (1993),
subsequent reports concentrated on the
qualified presence of the gating effect in OCD and its attenuation
in schizophrenia (P50, N1, P3) (1996),
and |