Asherson, P. & the IMAGE consortium

[ Consortium: - Antrop, I., Banaschewski, T., Buitelaar, J.K., Buschgens, C., Chen, W., Craig, I., Doyle, A., Ebstein, R.P., Eisenberg,J., Faraone, S.V., Gill, M., Knight, J., Kuntsi, J., Manor, I., McGuffin, P., Miranda, A., Mulas, F., Müller, U., Mulligan, A., Oades. R., Plomin, R., Roeyers, H., Rommelse, N., Rothenberger, A., Sham, P., Schebaum-Stein, T., Sergeant, J.A., Sonuga-Barke, E.J.S., Steinhausen, H-C., Taylor, E.A., Uebel, H. ]

Attention-deficit hyperactivity disorder in the post genomic era. (2004) European Child and Adolescent Psychiatry, 13, suppl. 1, 50-70 .

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Introduction: ADHD: Genetic risk factors are expected to be multiple, have small effect sizes when considered individually & to interact with each other & with environmental factors.

1 - Considerable progress has been achieved through the association analysis of candidate gene loci. Linkage scans using affected sibling pairs have identified a number of potential loci that may lead to the identification of novel genes of moderate effect size.

2 - Quantitative trait locus (QTL) approaches provide powerful complementary strategies that have the potential to link the categorical disorder to continuously distributed traits associated more closely with underlying genetic liability in the general population.

3 - Success in identifying some associated genes has been complemented by functional studies that seek to understand the mode of action of such genes.