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O’DUSHLAINE, C. et al 2015
The Network and Pathway Analysis Subgroup of the Psychiatric Genomics
Consortium (RDO 189th of 370 co-authors), Introduction: We sought to identify biological
pathways in GWAS data from over 60,000 participants from the Psychiatric
Genomics Consortium. We developed an analysis framework to rank pathways
that requires only summary statistics. Results: 1/ Histone methylation processes showed the strongest association, and 2/ we also found statistically significant evidence for associations with multiple immune and neuronal signaling pathways and with the postsynaptic density. 3/ In contrast, three negative control phenotypes (height, inflammatory bowel disease, and Parkinson's disease) did not show this enrichment. Discussion: a) Our study indicates that risk variants for psychiatric disorders aggregate in particular biological pathways and that these pathways are frequently shared between disorders. b) Our results confirm known mechanisms and suggest several novel insights into the etiology of psychiatric disorders. |