O’DUSHLAINE, C. et al 2015 The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium (RDO 189th of 370 co-authors),
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience 18, 199-209

Introduction: We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an analysis framework to rank pathways that requires only summary statistics.
We combined this score across disorders to find common pathways across 3 adult psychiatric disorders: schizophrenia, major depression and bipolar disorder.


1/ Histone methylation processes showed the strongest association, and

2/ we also found statistically significant evidence for associations with multiple immune and neuronal signaling pathways and with the postsynaptic density.

3/ In contrast, three negative control phenotypes (height, inflammatory bowel disease, and Parkinson's disease) did not show this enrichment.


a) Our study indicates that risk variants for psychiatric disorders aggregate in particular biological pathways and that these pathways are frequently shared between disorders.

b) Our results confirm known mechanisms and suggest several novel insights into the etiology of psychiatric disorders.