![]() |
![]() |
![]() |
VAINIERI, I., Martin, J., Rommel, A-S., Asherson, P., Banaschewski, T., Buitelaar, J., Cormand, B., Crosbie, J., Faraone, S. V., Franke, B., Loo, S., Miranda, A., Manor, I., Oades, R. D., Purves, K., Ramos-Quiroga, J. A., Ribases, M., Roeyers, H., Rothenberger, A., Schachar, R., Sergeant, J. , Steinhausen, H-C., Vuijk, P. J., Doyle, A.E., Kuntsi, J., 2021 Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments, Psychological Medicine, 1-9. https://doi.org/10.1017/S0033291720005218. Abstract -- Polygenic risk scores (PRS), derived from the GWAS, can be used to assess genetic overlap between ADHD and other traits. -- Using ADHD samples from several international
sites, we derived PRS for ADHD from the recent GWAS 0/ The discovery GWAS included 19,099 ADHD cases and 34,194 control participants. The combined target sample included 871 people with ADHD (age 8-40 years). -- RTV and CE were available from reaction time and response inhibition tasks. -- ADHD PRS were calculated from the GWAS using a leave-one-study-out approach. -- Regression analyses were run to investigate whether ADHD PRS were associated with CE and RTV. -- Results across sites were combined via random effect meta-analyses. 1/ When combining the studies in meta-analyses, results were significant for RTV (R2=0.011, ß=0.077, p<0.01) but not for CE (R2=0.016, ß=0.011, p=0.775). 2/ No significant association was found between ADHD PRS and RTV or CE in any sample individually (p>0.10). Conclusions: We detected a significant association between PRS for ADHD and RTV
(but not CE) in individuals with ADHD, suggesting that common genetic
risk variants for ADHD influence attention regulation. |